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Browns vs. Colts Prediction, Player Prop Bets & Odds for 10/22

Oct 15, 2023; Cleveland, Ohio, USA; Cleveland Browns wide receiver Amari Cooper (2) runs the ball as San Francisco 49ers cornerback Deommodore Lenoir (2) pulls him down from behind during the fourth quarter at Cleveland Browns Stadium. Mandatory Credit: Scott Galvin-USA TODAY Sports

The Cleveland Browns head into their NFL Week 7 tilt against the Indianapolis Colts with renewed excitement for the season after moving to 3-2 with a huge win over the San Francisco 49ers last week. Starting as double-digit underdogs with practice-squad QB PJ Walker getting his first start for the team, the Browns defense shut down the previously unbeaten 49ers offense in a season-changing 19-17 win. The Colts are 3-3 but coming off a 37-20 AFC South loss to the Jacksonville Jaguars.

We have a Browns vs Colts prediction for the crucial AFC matchup on Sunday, plus news of a great offer for new customers from DraftKings Sportsbook which means you can sign up here to claim $200 in bonus bets when you place your first bet of $5 or more. That could be on our Browns vs. Colts prediction or any NFL Week 7 game of your choice.

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Now let's take a look at our Browns vs. Colts prediction available at DraftKings Sportsbook.

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CLEVELAND BROWNS VS. INDIANAPOLIS COLTS PREDICTION: Browns ML (-130) at DraftKings Sportsbook

If you're ready to place a wager with our Browns vs. Colts prediction, tap the link here to join DraftKings Sportsbook in time for Sunday's opening kickoff.

Cleveland Browns vs. Indianapolis Colts Prediction for NFL Week 7

The Browns hope to have starting QB Deshaun Watson back for their trip to Indianapolis, but the Colts will not have Anthony Richardson at QB as the rookie is contemplating season-ending surgery. That could mean they ride with Gardner Minshew the rest of the way, and while he's one of the best backups in the league it's not what the Colts were planning for and nor was the six-game suspension handed to defensive tackle Grover Stewart this week.

The Browns showed in last week's win that their league-leading defense means they can be competitive even when starting a backup quarterback and it's worth noting that they were also missing star offensive lineman Joel Bitonio for the first time in more than 100 games and he could be back this week. Even if forced to use Walker again, the Browns should have a good shot to make it back-to-back wins after running back Jerome Ford managed an impressive 84 rushing yards against the tough 49ers defense.

The Colts struggled as the Jaguars completed a quick season sweep over them last week and they will have a better chance of winning if Watson remains on the sidelines, but they are already 1-2 at home this season and the Browns will feel that if they can beat the 49ers they can beat anyone. Our experts like the Browns on the money line, which is available at -130 odds at DraftKings Sportsbook.

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Browns vs. Colts Prop Picks & Best Bets Featuring Amari Cooper and Jerome Ford

Due to the uncertainty surrounding the Browns' QB situation, there is a lack of player props available for this game at the time of publishing. DraftKings does, however, have a special market on offer, which is for Browns running back Jerome Ford and wide receiver Amari Cooper to combine for 180 or more rushing and receiving yards. As the odds of +220 suggest, it's not a price that has huge appeal unless Watson returns. Even so, the pair led the way on the ground and in the air respectively against the 49ers, with Ford posting 91 all-purpose yards in the game and Cooper proving to be the one man that Walker could find with any regularity, snaring four catches for 108 yards. With much better playing conditions expected this week at Lucas Oil Stadium, it's far from out of the question for this special prop to hit on Sunday.

Our preference is for a more standard prop in the game, however, and that's for the Browns to score over 19.5 points at -125 odds at DraftKings. The Browns scored 24, 22 and 27 points in their first three games with Watson at QB, but managed only 3 against the Ravens with rookie Dorian Thompson-Robinson at QB and 19 against San Francisco with Walker. Whether it's Walker or Watson this week, the Browns look good to reach at least 20 points in Indianapolis.

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How to Follow Browns ML at DraftKings Sportsbook to Redeem a $200+ Sign-Up Bonus

You can bet on the Browns ML or the Browns to score more than 19.5 points against the Colts at DraftKings Sportsbook. Take advantage of this exclusive new-customer offer today. When you sign up for a DraftKings account using this link and make your first bet of $5 or more, you will automatically receive $200 in bonus bets, whether that wager is successful or not.

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Latest Browns vs. Colts Odds, Spread & Betting Lines for 10/22 Available at DraftKings

DraftKings Sportsbook has a great range of markets available for Sunday's NFL Week 7 games, if you want to bet on Browns vs Colts prediction or any other market.

The visiting Browns are -130 odds money line favorites at DraftKings, with the Colts ML available at +110.

The spread for the game has been set at +2 points, with the Browns -2 and Colts +2 both listed at -110 odds.

The game total line is fairly low at 39 points, this time with -112 odds on over 39 and -108 on under 39.

Click here to register for a new DraftKings Sportsbook account and you’ll be on your way to claiming $200 worth of bonus bets instantly when you bet just $5 on any sport.

49ers vs. Browns Highlights: Stats Last Week

The San Francisco 49ers' average result as they cruised to a 5-0 record had been a win by 19.8 points, yet they could score only 17 points against the Browns defense. That Cleveland unit, masterminded by DC Jim Schwartz, is recording some historically notable marks, and has allowed just 200.4 yards per game, which is 60.4 yards better than the second-best mark of the Ravens. Browns backup QB PJ Walker passed for 192 yards against the 49ers, whose own QB Brock Purdy suffered his first regular-season loss after being held to 125 yards while completing only 12 of 27 pass attempts.

Veteran Kareem Hunt got the early work in the Browns backfield, but finished with 47 rushing yards and a touchdown from his 12 carries, while Ford came on strong in the second half to finish with 84 yards on 17 carries.

Whether or not you want to back our Browns vs Colts prediction for Sunday, be sure to use this link to claim your DraftKings new customer bonus and receive $200 in bonus bets for your first $5 wager.

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