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Bills vs. Chargers Prediction, Best Bets & Odds for Saturday, 12/23

The Buffalo Bills will be trying to continue their winning ways when they visit the Los Angeles Chargers in Week 16 of the NFL season on Saturday night. Buffalo is coming off back-to-back huge victories over Kansas City and Dallas, going from 6-6 and 8-6 to keep its playoff hopes alive. Los Angeles, on the other hand, just cleaned house after falling to 5-9 with a humiliating 63-21 loss to Las Vegas.

Do the Chargers have any fight left in them for the remainder of the 2023 campaign, or will the heavily favored Bills take care of business? Our experts have broken down the Bills vs. Chargers odds and are ready to deliver their Bills vs. Chargers prediction.

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BILLS VS. CHARGERS PREDICTION: Bills -12.5 (-110 at FanDuel Sportsbook)

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Bills vs. Chargers Prediction for Saturday, 12/23

Our experts’ first Bills vs. Chargers prediction is on the visitors to cover a -12.5 spread.

Buffalo appears to be getting hot at just the right time. With a .500 record through 13 weeks, head coach Sean McDermott’s squad was on life support in terms of postseason aspirations – especially with games against the Chiefs and Cowboys looming large. Well, the Bills won both of those contests and looked especially impressive during a 31-10 beatdown of the Cowboys last weekend. Quarterback Josh Allen has been playing at an MVP level over the past month and running back James Cook went crazy to the tune of 221 yards from scrimmage and two touchdowns against Dallas.

Of course, what you really have to like about the Bills’ chances is that they are playing the Chargers. This is a team that just fired its head coach (Brandon Staley) along with the general manager and several other staff members. Los Angeles is in complete disarray following its embarrassment against the Raiders and it has lost five of its last six games overall. QB Justin Herbert is out for the season, too, so Easton Stick will once again be under center on Saturday.

All things considered, our best Bills vs. Chargers prediction is Buffalo -12.5.

Bills vs. Chargers Best Bets & Free Picks

If you want additional Bills vs. Chargers best bets, you have come to the right place. To go along with our experts backing Buffalo against the spread, they also are also making a Bills vs. Chargers prediction that has the score going over the total – which is set at 43.5 points.

An in-form Buffalo offense has scored at least 31 points in three of the last four contests. Now it faces a Los Angeles team that one week ago gave up a ridiculous 63 points to Las Vegas. On the other side of the ball, Stick at least managed to find some success in his first start of the season against the Raiders – albeit in garbage time. He finished with 257 yards through the air and three touchdowns.

The Bills will likely do a ton of scoring this weekend, while the Chargers should be able to contribute just enough to take this total over a modest 43.5 number.

How to Bet on the Bills Against the Chargers at FanDuel and Get Up to $150 in Bonus Bets

Now that you know our experts’ Bills vs. Chargers prediction and can decide whether to tail or fade those Bills vs. Chargers best bets, let’s break down how you can capitalize on the latest FanDuel sign-up bonus:

  1. Use this link to create a new account at FanDuel
  2. Deposit at least $10
  3. Wager at least $5 on any pre-game money line
  4. Receive $150 in bonus bets if your team wins

Although our experts like Buffalo to cover the spread, betting on the visitors’ money line is obviously much safer since with that wager their margin of victory doesn’t matter. Even if the Bills win by just one point, the money line bet is successful. As such, this is arguably the best NFL money line bet to make in Week 16 since Buffalo is the biggest favorite on the entire schedule.

Rather than needing the Bills to win by at least 13 points, you can simply root for them to win outright and still effectively get them at 30/1 odds with this FanDuel Sportsbook bonus! There is no FanDuel promo code needed for this ‘Bet $5, get $150’ offer, too, so you can simply click here to get started right now.

Bills vs. Chargers betting odds for Saturday, 12/23 via FanDuel Sportsbook

Before you can make the best possible Bills vs. Chargers prediction, it is important to know the Bills vs. Chargers odds.

Buffalo is a -12.5 favorite on Saturday, making Los Angeles a +12.5 underdog. Both teams are priced at -110. That means an $11 bet on the Bills is successful and returns $10 of profit if they win by at least 13 points; an $11 wager on the Chargers gets you $10 of profit if they either win outright or lose by no more than 12 points.

On the money line, Buffalo is -675 and Tennessee is +490. A $67.50 wager on the Bills returns $10 in winnings if they get the job done; a $10 bet on the Chargers nets $49 in profit if they pull off the outright upset.

The game total, or over/under, is set at 43.5 and both sides come with -110 odds. That means an $11 wager on the over is successful and nets $10 of profit if the two teams combine for at least 44 points. An $11 bet on the under returns $10 in winnings if no more than 43 points are scored.

Bills Injury Report Ahead of Saturday’s Game, Will James Cook Play?

We have factored the injury reports into our Bills vs. Chargers best bets, which you always want to do before any game kicks off.

A word of caution before cementing your Bills vs. Chargers prediction in stone is that Buffalo has a couple of key offensive players in doubt for Saturday. Cook is questionable due to illness and tight end Dalton Kincaid is questionable because of a shoulder injury. 

For Wednesday’s practice, Cook was a non-participant and Kincaid was limited. The red-hot running back’s potential absence would be an especially significant blow to the Bills’ offense, but nonetheless, they have a good chance to cover the spread against a reeling Los Angeles team regardless of the injury issues. If you want to wager on this matchup click here and sign up for a new account with FanDuel Sportsbook.

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